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Retatrutide Dosing Protocols for Research The Jastreboff et al
The maintenance doses used in these trials include: 4 mg once weekly 9 mg once weekly 12 mg once weekly For those taking the maximum 12 mg dose , they follow a gradual increase that looks like this: 2 mg 4 mg 6 mg 9 mg 12 mg (highest dose studied) Each increase happens every 4 weeks , similar to the phase 2 studies, so the full build-up takes about 16 weeks before staying at 12 mg for the rest of the study
This is also observed in mild cognitive impairment (MCI) which is a preclinical stage of AD
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Since NAc is also considered a part of striatum, we decided to use striatal tissues, which include NAc, for our co-immunoprecipitation experiment