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Alterations in DDR If DNA damage is not repaired promptly, cellular senescence or apoptotic signals are activated, while abnormal activation of DDR maintains the viability of cancer cells, significantly inducing resistance to chemotherapeutic drugs and PARPis and affecting therapeutic efficacy [38]

Once released, GLP-1 sends signals to different parts of the body to help manage digestion and hunger

Next-generation, long-acting, and patient-friendly formulations are advanced drug versions designed to work over extended periods, reduce dosing frequency, and make treatment easier and more convenient for patients

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In May 2026, the EMA's CHMP adopted a positive opinion recommending approval for Wegovy oral tablets for weight management, adding lifecycle-management opportunities across semaglutide, dulaglutide, and other GLP-1RA classes

The practical ceiling for most patients in the first year falls between 15 and 20% of body weight