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[15] Serious but infrequent events-such as angioedema, bronchospasm, hypotension, or urticaria-reflect IgE-mediated hypersensitivity and may require desensitization or substitution with hydroxocobalamin

Understanding the differences between cyanocobalamin and hydroxocobalamin helps healthcare providers

Hydroxocobalamin is the preferred agent in this patient population (see separate monograph in Less Common Drugs)

What This Program Supports|Cellular energy production and metabolism

Intramuscular (IM) : Common sites include the upper arm (deltoid muscle), thigh (vastus lateralis), or buttocks (gluteus medius)

The most common sites for B12 injections are the deltoid (upper arm), vastus lateralis (outer thigh), ventrogluteal (hip), abdomen, and outer upper arm for subcutaneous injections