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GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism

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While the canonical signalling pathway engaged upon MCR activation is the increase in cyclic-AMP, it was found that inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response (176), suggesting that the involvement of other pathways should be investigated to understand these actions