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Diabetic retinopathy Rapid improvement in glycaemic control, particularly with semaglutide, may temporarily worsen diabetic retinopathy

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It's a sequence that makes it very long lasting

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[1] [2] The pharmacokinetic properties of each medication determine its recommended dosing frequencysemaglutide and tirzepatide are typically administered once weekly due to their longer half-lives (approximately one week for semaglutide), whilst liraglutide has a shorter half-life (approximately 13 hours) and requires daily injections