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Overall mouse health was assessed by daily inspection for signs of discomfort, weight loss, or changes in behaviour, mobility, and feeding or drinking habits
Toxicol Sci
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The SELECT, STEP, and ESSENCE programs collectively support its role across this spectrum, with robust efficacy but a characteristic GLP1 RA tolerability profile that necessitates careful initiation, titration, and monitoring
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These ensure the pancreas releases sufficient insulin when the blood glucose level is high
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