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Using a L-5-methyltetrahydrofolate instead of folic acid, and ensuring we have optimal B12 in the form of methylcobalamin, and vitamin B6 in P-5-P form are key in helping with these pathways

3d are tested for their binding properties with full agonist GLP-1 ( a ), and fragment antagonist exendin-4 (9-39) that targets the extracellular domain ( b )

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The image below highlights the mechanisms of both GLP-1 and GIP, along with a callout to the newest treatment optiona triple incretin that also includes glucagonexpected to be approved in late 2025 to early 2026