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The exact cellular mechanisms underlying the synthetic lethality of RSL3 on BRAF/RAS mutant PTC cells remain to be determined
PMID 1632422
doi:10.1155/2017/6274854 Chan YL, Saad S, Al-Odat I, et al
However, Arturi et al
3 provides an experimental platform for the parameterisation of the mathematical models
Studies conducted on rat -cells (47) and cell lines expressing recombinant GLP-1R and GIP-R in vitro and human islets (41) demonstrated that the adenylate cyclase was influenced by signals arising from the stimulation of both receptors, mainly deriving from GIP ( Figure 1 )
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