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Seek medical advice if you experience: Persistent or worsening sexual dysfunction that affects your quality of life or relationships, including sustained loss of libido, erectile dysfunction in men, or difficulty with arousal or orgasm in women New onset of sexual problems that began after starting tirzepatide and have not improved after the initial adjustment period during the first few weeks of treatment or dose increases Symptoms suggesting hormonal imbalance , such as irregular menstrual periods, hot flashes, breast tenderness, or signs of low testosterone in men (fatigue, mood changes, reduced muscle mass) Relationship distress related to changes in sexual function or body image during treatment Concerns about medication interactions , particularly if you are taking antidepressants, blood pressure medications, or other drugs that may affect sexual function Your healthcare provider can conduct a thorough evaluation to determine potential causes of sexual health changes

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Ageing Research Reviews, 26 , 96111