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Safety, Tolerability, and Provider-Guided Suitability Assessment Tirzepatide's common side effects include nausea, vomiting, and gastrointestinal distresstypically dose-dependent and manageable through slower titration

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GLP-1 agents, while costly and not yet guideline-endorsed for prevention, offer broader metabolic benefits without inherent bleeding risk

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and increased absolute and relative bioavailability, which may be the result of reducing first-pass metabolism in the intestine and liver