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These modifications in metabolism pathways resulted in a substantial increase in the levels of 48 metabolites such as Xanthine, ascorbate, Cys-Gly, kynurenine, phenylalanine, 5-hydroxykynurenine, and others as outlined in Supplementary Figures 5A, B

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DSIP was reported to modulate the stimulation of rat pineal N-acetyltransferase activity, an enzyme central to melatonin synthesis, by involving the alpha-1-adrenergic receptor (PMID 3029331)

C2C12 mouse myoblasts are widely used for studying IGF-1 LR3's effects on myogenic differentiation, myotube hypertrophy, and Akt/mTOR-mediated protein synthesis signaling

To differentiate between classically defined adult-onset and age-related GHD associated with the somatopause, the latter is often called growth hormone insufficiency (GHI)