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A medicine only helps if the patient actually takes it. When looking at the next research steps for elecoglipron, Carroll said he would like to see a phase 3 clinical trial involving thousands of patients over a year or more, to see where the blood-sugar and weight effects actually land and hold

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The additional receptor activation means there are more pathways being affected simultaneously, which some people experience as more noticeable initial adjustment

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The fatigue during early semaglutide use more likely results from caloric restriction, changes in eating patterns, and the medication adjusting appetite and satiety signals