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Adjustments can include slowing the titration schedule, increasing the pyridoxine component, adding ondansetron for breakthrough nausea, or switching to a different GLP-1 medication if semaglutide fundamentally does not agree with your system
Are there specific dosing requirements for patients with certain medical conditions
According to the manufacturer, milder or more common Contrave side effects include: Abdominal pain Altered taste Anxiety Constipation Diarrhea Dizziness Dry mouth Excessive sweating Fatigue Headache Heart palpitations Hot flush Increase in blood pressure Increase in heart rate Influenza Insomnia Irritability Muscle strain Nausea Rash Ringing in ears Stomach virus Tremor Trouble sleeping Urinary tract infection Vomiting This is not a complete list of potential side effects
In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]
There appeared to be a treatment-related asymptomatic increase in median serum lipase activity with liraglutide compared with placebo, otherwise no clinically relevant treatment-related changes in safety laboratory measures were apparent
Take a Weight-Loss Assessment Across multiple studies, people who were overweight or living with obesity and taking CONTRAVE, along with diet and exercise, lost 2-4x more weight than with diet and exercise alone
