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These accumulated DNA mutations are the cause for the decline in gene expression and loss of functional capacity seen with increasing age and may be mitigated by Cr

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Key mechanisms include the relief of hypothalamic-pituitary-ovarian (HPO) axis inhibition through weight loss and improved insulin sensitivity, alongside improved endometrial receptivity driven by increased SHBG and decreased free androgens (83, 167, 168)

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De esta forma, se favorece la reduccin de la grasa corporal y puede mantener un nivel de energa adecuado a sus necesidades

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Severe obesity or type 2 diabetes requiring urgent intervention If a patients body mass index (BMI) is in the severe or morbid obesity range, or if they have uncontrolled type 2 diabetes with high blood sugar levels and/or A1C, waiting for thyroid stabilization could delay needed care

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