It is clear that the CNS is necessary for GLP-1R mediated induction of visceral illness as mice with a CNS deletion of the GLP-1R develop conditioned taste aversion (CTA) to lithium chloride but not to liraglutide (Sisley et al., 2014)
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Similarly, the dual GLP-1R and GIP agonist tirzepatide promoted the intake of standard rodent chow at the expense of a high-fat diet in mice, suggesting a preferential shift toward less energy-dense foods (Geisler et al., 2023)
This is whats so disheartening when I see a patient who may have been suffering from histamine intolerance for months or even years, and theyve gone from article to article to the podcast to blog to video
GLP-1 medications are very effective at reducing calorie intake, so it may be especially challenging to eat less when you stop taking them
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