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Examining the between-group eGFR differences, after considering a finerenone associated acute decline in eGFR of 2.5 mL/min/1.73 m 2 compared to placebo, the finerenone group declined by 2.66 mL/min/1.73 m 2 /year versus a 3.97 mL/min/1.73 m 2 /year decline in the placebo group, with a crossing of the eGFR curves occurring at approximately 24 months

That deficit is the chief mechanism behind weight loss, but it does have its own downsides as well