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Pharmacological inhibition or genetic deletion of CytB5R3 increases NO availability in blood vessels (Straub et al., 2012)

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Key benefits for perimenopausal women: Targets visceral and subcutaneous fat accumulation that tends to increase as estrogen declines and metabolism slows Does not affect blood sugar or cause stimulant-related side effects such as anxiety or elevated heart rate Supports fat loss while preserving lean muscle tissue, important for maintaining metabolic rate during hormonal transition Administration method: Subcutaneous injection into abdominal fatty tissue, typically 2 inches from the navel