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We employed MR-Egger regression, weighted median, and modebased estimators (including both weighted and simple mode) to obtain robust causal effect estimates even if a subset of the instruments were invalid

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Peptides: Tesamorelin, AOD9604, Tirzepatide (GLP-1 agonist) Tesamorelin is FDA-approved to reduce visceral adipose tissue (VAT) in HIV-associated lipodystrophy, but its fat-burning effects also appear in non-HIV populations AOD9604 is a modified fragment of human GH (176191) shown in animal and early human trials to enhance lipolysis without altering blood sugar or cortisol Tirzepatide , while technically a GLP-1/GIP agonist , is now frequently stacked with peptides in clinical practice to accelerate fat loss and appetite control

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Inoue, and M