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However, in line with our confirmation of the FBP-mediated phenotypes in four different cell lines (U-2 OS, MDA-MB-231, RPE-1 and HFF), RNA-based expression profiling demonstrates that RCC2 is widely expressed with above-median levels in dendritic, endothelial and -cells 82 consistent with a potential FBP-orchestrated regulatory role in those cells, a hypothesis that remains to be tested