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Marker groups consisting of SDC2 and SEPT9 were detected in urine sediment of CRC cases with a specificity of 70%, showing promise for non-invasive CRC detection through urine liquid biopsy ( SEPT9 plays a crucial role in cell division, and its hypermethylation process is linked to carcinogenesis and can alter the conformation of gene sequences

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The composite PCR amplification curves and the linearity plot from 15 to 10000 IU/mL of the 5th WHO International Standard for HCV are shown in Fig

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Inclusion and exclusion criteria The inclusion and exclusion criteria are summarised in Table 1