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The proof is largely in vitro and animal research with minimal studies on people
In women being evaluated for ovulatory dysfunction or subfertility, mid-luteal serum progesterone is the key functional test
The most commonly reported ones include nausea, vomiting, indigestion, diarrhea, constipation, abdominal pain, and stomach upset, which go away on their own for many people as their body gets used to the medication
10.1093/ajcn/80.6.1611 78 JamesS
Additionally, metformin may stimulate ovulation in those with polycystic ovary syndrome (PCOS) or who are premenopausal
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