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They can - and heres how: its likely you wont wait for your filler to entirely break down before you come back in, so when we inject filler on top of filler, and especially when that filler is placed in the same area, then the actual HA molecules should have less surface-area-contact with your tissues, which in studies has been shown to allow them to be more resistant to breaking down - making them last longer

Who Is a Good Candidate for Lipo Shots

Dundee, J

Blunted or impeded therapeutic response to vitamin B12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency

doi: 10.1007/978-3-8274-2440-2_7 144 BreitbartWRosenfeldBTobiasKPessinHKuGYYuanJet al

The Short and Long Answer Yes, it expires