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Chemically, tirzepatide is a synthetic linear peptide containing 39 aminoacids based on the native GIP sequence
(2020) 26:657674.e8
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Int J Cancer (2017) 140(11):245160
In the TMLHE gene knockout mouse model, the carnitine biosynthetic pathway is inhibited due to the loss of TMLD activity in the liver, affecting the availability of carnitine in the heart, significantly reducing the rate of synthesis of LCACs, and contributing to the protection of mitochondrial function after myocardial IRI [215]
LABRUTO G et al
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