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JAK/STAT, Janus kinase/signal transducer and activator of transcription

[16] revealed that lactate induces histone lysine lactylation, influencing gene transcription in a dose-dependent manner

In transgenic mouse experiments, TFAM overexpression not only increased the mtDNA copy number in mouse hearts by approximately 2-fold but also, under volume overload (VO) conditions, inhibited the production of mitochondrial reactive oxygen species (mitoROS), reduced the activity and abnormal upregulation of MMP-2/9, ultimately alleviating eccentric myocardial hypertrophy, improving cardiac function, and causing no damage to mitochondrial enzyme activity (155)

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3.1.2 Other PEDs This group included other substances prohibited by WADA, such as non-approved substances (BPC-157) from Section S0, other anabolic agents (clenbuterol and SARMs) from Subsection S0, S1.2, peptide hormones and their releasing factors (AOD-9604, hGH 176-191, CJC-1295, ibutamoren, ipamorelin, and growth hormone-releasing peptide) from S2.2, growth factors and growth factor modulators (thymosin-4 and its derivative TB-500) from S2.3, beta-2 agonists (salbutamol and indacaterol) from S3, metabolic modulators (meldonium, GW1516, SR9009, SR9011, and insulins) from Section S4.4, and thyroid hormones

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