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Accumulation of SnCs during aging is due to the decrease of immune surveillance, probably related to dysregulation of pathways involved in the immune system activation 41,42

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Calculating 13 C-labelling enrichment in the detected metabolites The distribution of 13 C-labelling from arginine or proline in the identified metabolite pool was determined by calculating the ratio of 13 C to 12 C in the major mass fragments