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In addition to the beneficial effects on weight loss, prolonged water fasting has been shown to alter the gut microbiome [3], improve blood pressure [4, 5], and lower inflammation markers [6]

January 2026: Amgen completed Phase 3 enrollment for MariTide (AMG 133) in the MARITIME-Obesity trial, with interim efficacy data expected in Q3 2026 that will position the monthly injection GLP-1/GIP antagonist as a once-monthly obesity treatment alternative

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Their combination is mechanistically complementary that is the published research rationale, not a claim of additive efficacy

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