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NICE NG73 and BSGE guidance recommend add-back therapy and, where appropriate, calcium and vitamin D supplementation

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13% of the participants treated with the combined compound ended up discontinuing the trial, while 10% of the participants treated with semaglutide discontinued, however, none of the participants treated with cagrilintide discontinued their treatment plan indicating that cagrilintide was the most well tolerated by the study participants [2]

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