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Hypokalemia, hyponatremia, chronic and acute kidney problems, along with other electrolyte imbalances, are all potentially dangerous side effects. Every day, doctors and patients face a decision about which thiazide diuretic to use and are waiting for evidence so this high-quality study provides the best evidence so far and suggests that the one we have been using most often, hydrochlorothiazide, is better, says co-author Harlan Krumholz, MD, SM, a professor of medicine (cardiology), epidemiology and public policy at Yale University

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