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However, high doses may cause side effects such as nausea, vomiting, diarrhea, and constipation

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Phase (approx.) Cagrilintide dose Frequency Weeks 14 0.25 mg Once weekly Weeks 58 0.5 mg Once weekly Weeks 912 1.0 mg Once weekly Weeks 1316 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021

The median of current age, the onset of symptoms and the time since diagnosis were 12.2 years (8.520.9), 12.0 months (6.012.0) and 7.1 (4.413.1) years, respectively

Mezzetti A et al

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