FIGURE 6 Physiological Role of Ketosteroid Isomerase Steroid hormone production is key to regulation of numerous physiological functions
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However, its impact on endosomal escape requires careful optimization, as PEG can hinder LNP fusion with endosomal membranes, a phenomenon often referred to as the PEG dilemma 174,175,176
Toxicol Mech Methods
Studies have demonstrated that daily oral administration of crystalline cyanocobalamin effectively normalizes serum cobalamin levels in deficient patients, although it is unsuitable for rapid supplementation in cases of severe deficiency due to the limited passive absorption
It is important to note that other families of GSTs, absent in mammals, are also described in the literature