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In addition, the short duration of the study (45 weeks) and low effective doses of TRZ and semaglutide may limit the neuroprotective effects of these agents in AD models

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Semaglutide has a median onset of 4 days, liraglutide 3 days, and dulaglutide and exenatide around 1 day

It has been shown that GLP-1 analogue exenatide could activate the human monocyte-derived macrophage towards M2 phenotype ( -/- mice with a concomitant upregulation of M2 marker CD163 ( +/- mice, a -cellspecific glucokinase haploinsufficient (Gck+/) diabetic model ( 2.2 The role of GLP-1 in innate-like T lymphocytes Invariant Natural Killer T (iNKT) cells are a subpopulation of T lymphocytes that bridge the innate and adaptive immune systems ( 2.3 The role of GLP-1 in intestinal epithelial lymphocytes As a innate like lymphocytes, intestinal epithelial lymphocytes (IELs) patrol the lamina propria and play a critical role in host-bacteria interaction, wound healing, mucosal growth and regeneration, and inflammation ( -/- mice, while the numbers of CD4+ and CD8+ T cells and B cells in the spleen and lymph nodes had no differences (49)

Spinach, broccoli, avocado, asparagus, okra, garlic, and walnuts are some such foods that are rich in glutathione or help stimulate its production

Abbreviations Al 2 O 3 : aluminum oxide ALCAR: acetyl-L-carnitine Apaf-1: apoptosis protease activating factor-1 CACTL: carnitine: acylcarnitine translocase FBS: fetal bovine serum GO: gene ontology GSH: glutathione H 2 O 2 : hydrogen peroxide HBE: human bronchial epithelial HE: hematoxylin and eosin HEPG2: human hepatocarcinoma KEGG: Kyoto encyclopedia of genes and genomes MDA: malondialdehyde MOMP: mitochondrial outer membrane permeabilization NPs: nanoparticles O 2 .- : superoxide PFA: paraformaldehyde PM 2.5 : fine particulate matter ROS: reactive oxygen species SE: standard error of the mean SWCNTs: single-walled carbon nanotubes TBA: thiobarbituric-acid References Mills NL, Donaldson K, Hadoke PW, Boon NA, MacNee W, Cassee FR, et al