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The five subtypes (MC1R to MC5R) are class A G-protein-coupled receptors that signal principally through Gs and adenylyl cyclase to raise intracellular cAMP, and the conserved His-Phe-Arg-Trp core of alpha-MSH is the message sequence recognised by the binding pocket

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Beyond that, the head-to-head study against tirzepatide and the REDEFINE 3 cardiovascular trial are both ongoing and expected to deliver readouts through 2026 and 2027

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The two studies are being presented this week at the joint conference held by the Society for Cardiovascular Angiography & Interventions (SCAI) 2026 Scientific Sessions & Canadian Association of Interventional Cardiology (CAIC)