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The real problem is the misinformation and regulatory vacuum around many of them

Some psychiatric medications, particularly certain mood stabilisers, require regular blood tests to monitor therapeutic levels and organ function

The increase in heart rate in retatrutide trials is the side effect that regulators and clinicians are watching closely

Patients should contact their GP or prescribing clinician if they experience: Severe or persistent cramps that do not respond to simple measures or significantly impact daily activities and sleep quality Frequent cramping occurring multiple times daily or nightly Associated symptoms such as muscle weakness, numbness, tingling, or changes in sensation, which may indicate neurological involvement Visible muscle changes including swelling, redness, tenderness, or asymmetry between legs Signs of dehydration such as dizziness, reduced urine output, dark urine, or confusion These features may indicate underlying conditions requiring investigation, such as significant electrolyte disturbances, peripheral neuropathy (particularly relevant in diabetes), peripheral arterial disease, or, rarely, more serious muscle disorders

A double-blind, placebo-controlled study found that patients on memantine had a substantial response, suggesting that it could be a justified treatment for these disorders

The gastric balloon could be an option for patients who are not good candidates for surgery or dont respond well to weight-loss drugs, Traverso says