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As expected, from a pharmaco economic perspective, the impact of SGLT-2i on HHF prevention will be in proportion of the individual risk of the event, with a substantial difference also between subjects with preserved or reduced EF

From its initial use in the treatment of type 2 diabetes to its expansion to 12 indications such as obesity, cardiovascular disease, chronic kidney disease, and metabolic dysfunction related fatty liver disease (MASLD), the annual sales of GLP-1 drugs exceeded 100 billion dollars, and its research and development funding reached a historical peak of 21.72 million dollars in 2025

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Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJP, et al