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Change You May Notice B12 Injection Oral Supplement More energy About 1 to 2 days Several weeks Mental clarity About 3 to 5 days 4 to 6 weeks Mood support About 1 to 2 weeks 1 to 2 months What Affects How Quickly a B12 Shot Works for You If you are comparing notes with a friend and wondering how fast a B12 shot works for them versus you, a few things explain the difference: Your starting levels

Timing considerations AOD 9604 works best when injected in a fasted state

If your levels are low, youll likely feel a gradual improvement in your energy and overall mood over the following days and weeks as your body puts the vitamin to use

While more research is needed, the current evidence supports B12 as a treatment for nerve pain