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In our translational work, we also reported a link between LAC levels, cellular aging and metabolic function in the antidepressant responses to the insulin-sensitizing agent pioglitazone, an agent for treatment of diabetes type 2 and tested as potential antidepressant [60]
The following sgRNAs for GGT1 CRISPRi were used: sgGGT1 1 (HL-ID: 3) forward: 5-CACCGGTGCCTCCCACTGTCCGCCG-3
krlec, K., Ruman, R., Jarc, E., Sikiri, P., vajger, U., Petan, T., Perii Nanut, M., trukelj, B., & Berlec, A
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Its also not as bioavailable as other protein types
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