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10.1016/j.bbrc.2004.03.110 Biochem

A recent study also demonstrated mislocalization of APE1 from the nucleus to the cytoplasm as a possible trigger of oxidative DNA damage in spinal motor neurons expressing mutant SOD1 G93A , despite upregulation of multiple DNA repair enzymes, suggesting that restricted localization of APE1 could inhibit redox homeostasis (Li J

Both support once-weekly dosing, which simplifies administration protocols

In office clinical peels have a low pH with higher bioavailability of glycolic acid & much higher concentrations, ranging from 20 to 70%

Both can be administered intranasally or subcutaneously and the reconstitution approach differs by route

For B12 injections, needles with gauges ranging from 25 to 30 are often used