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5.6 Hypersensitivity Reactions There have been postmarketing reports of serious hypersensitivity reactions (e.g., anaphylaxis, angioedema) in patients treated with tirzepatide
However, since the tubular reabsorption occurs via an active transporter, once the transporter is saturated by the high plasma L-carnitine concentrations achieved by intravenous administration, the circulating L-carnitine is rapidly excreted
It describes them as most appropriate for patients who cannot tolerate GLP-1 medications, those with a GLP-1 contraindication such as personal or family history of medullary thyroid carcinoma, or people whose situation calls for a different metabolic pathway
Scope note: All mechanisms and endpoints described below refer to published in-vitro assays or animal-model studies
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