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What this regulatory complexity means for strategic planning is that the pharmaceutical supply chain is being pressured from multiple directions simultaneously: from below by Cost Plus-style transparency and generic competition, from above by government price negotiation and MFN requirements, and laterally by the FTCs enforcement actions against PBM anticompetitive practices
Sulfonylureas target ABC transporters (hsa02010), yet these were not identified in the enrichment analysis for AD or DM2, despite their role in drug metabolism, BBB permeability, and -amyloid clearance 79,80
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Mechanotransduction and cell biomechanics of the intervertebral disc
Dub-Demers R et al
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