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British Journal of Pharmacology, 179 (4), 727742

The review also covered three therapeutic research strategies: direct GSH depletion (leading to ferroptosis or enhanced chemotherapy sensitivity), indirect approaches targeting the tumour microenvironment, and prodrug strategies utilising elevated tumour GSH for drug activation

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The compound's fatty-acid modification introduces an oxidation-sensitive feature beyond standard peptide-bond hydrolysis pathways, so light protection matters more here than for unmodified peptide compounds

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