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Eric Topol (35:46): Yeah, no, I think that's really interesting what you're bringing up

Incidence is higher in people of Black Caribbean and South Asian heritage

However, leptin levels have not been shown to differ significantly between individuals with PWS and those with simple obesity [28,29]

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However, both medications do not target glucagon (GCG) receptor (GCGR)

For FDA-approved GLP-1 medications, contraindications include a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, and a history of severe allergic reaction to the drug