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These multiple evidence suggest that impairment in GABAergic transmission plays a significant role in the pathophysiology of depression (99)

Visible particles mean the formulation has destabilized or been contaminated

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In a randomised, placebo-controlled double blinded phase 1 study of ascending single doses in healthy overweight humans, cotadutide was shown to be safe and, in common with the GLP-1 analogues, to be associated with dose-dependent gastrointestinal adverse events especially nausea and vomiting

Similar-looking pens may contain different active ingredients, deliver different doses, or have different approved uses

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