Measurable Outcomes in Neuropathy Symptom Improvement Studies have shown B12 can improve symptoms of neuropathy
[114] This functionality is lost in vitamin B 12 deficiency, and can be measured clinically as an increased serum methylmalonic acid (MMA) concentration
Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses
However, each metabolic intermediate in the DNL pathway (i.e., citrate, acetyl-CoA, malonyl-CoA, and palmitate) also has second messenger functions
Reber, S
B12 is a water-soluble vitamin involved in several normal body processes, including red blood cell formation, nerve function, and energy metabolism