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Patients on tirzepatide lost more weight at every dose level compared to semaglutide

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Its short half-life, however, required it to be injected several times a day, which limited its appeal as a drug, and the company ran out of funding

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The fact that GLP-1R agonists have beneficial effects on both energy and glucose metabolism places this class of pharmacotherapies at a superior level compared to other drugs used to treat T2DM that cause weight gain