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Xolair (Roche): $3.7B US sales in 2025, losing exclusivity now after 23 years Only Celltrion has an approved biosimilar ready Pomalyst (BMS): $2.34B US sales at risk One of many drugs losing patent protection from BMS recently/upcoming Opsumit (J&J): $1.63B US sales Already facing direct competition from Merck's Winrevair 10 generic manufacturers are ready to go with FDA approval Januvia/Janumet (Merck): $1.27B US sales 25+ generic settlements already in place Also losing US exclusivity: Simponi (J&J): $1.19B - autoimmune TNF blocker Mavenclad (Merck KGaA): $716M - relapsing MS Gattex (Takeda): $707M - short bowel syndrome Trintellix (Takeda): $698M - major depressive disorder Briviact (UCB): $652M - epilepsy Xeljanz (Pfizer): $625M - rheumatoid arthritis --- Patent expiry doesn't necessarily mean competition

Abbasi J (2026)

Zero Ultra is colloquially described as The White Monster because the can is white and features a grey "M" on the front that's the Monster logo, which is stylized to look like claw marks

GLP-1 patches may be trending, but theyre not a medically recognised treatment

The combination of reduced food volume and slower gastric transit creates conditions favoring this issue

A Natural Libido Booster Through Neurological Activation Although PT-141 is a synthetic peptide, its mechanism mimics the bodys natural signaling processes