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The Route of Administration The most significant barrier is that hydroxocobalamin is licensed for parenteral administrationmeaning it must be given by injection (Intramuscular, IM)

Advocates of this approach claim that regular injections can boost energy levels and help with weight loss and mood

The standard research protocol is 300 mcg per day, subcutaneous, administered in a fasted state, typically in the morning before food or exercise

These forms can be taken in tablet form and bypass potential barriers caused by genetic variants

Tell the pharmacist about all allergies and previous reactions, including a known cobalt allergy

doi:10.1038/s42255-023-00917-5