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The community of approximately 38 trillion microorganisms inhabiting the human colon, including bacteria, fungi, viruses, and archaea

When this conversion is impaired due to reduced methylfolate, homocysteine accumulates in the blood, causing inflammation and oxidative stress in blood vessels

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Paul and Brady also note that various single-nucleotide polymorphisms (SNPs) may influence the efficacy and bioavailability, but that at this time there is neither sufficient clinical research in this area nor are tests for these SNPs commercially available