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Treatment approaches developed for Western (Fitzpatrick IIII) skin do not translate safely or effectively to Indian skin and can cause paradoxical worsening or trigger new post-inflammatory hyperpigmentation (PIH) if incorrectly applied

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Studies showed that inhibitory activity could increase up to 1000-fold due to interactions between the cyano group and the O-atom of the serine side chain in the catalytic domain of DPP-4 (85) (Figure 4)

The human clinical research on CJC-1295 and Ipamorelin, while generating interest, is limited in scale and scope compared to FDA-approved medications