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Biochemical and omics biomarkers in cognition Classical CSF and plasma biomarkers A40 / A42 (important ratio in amyloid pathology) Total tau / p-tau181 / p-tau217 (tauopathic markers) Neurofilament light (NfL) : axonal degeneration marker GFAP : astrocytic activation BDNF and pro-BDNF : neurotrophic activity IL-6, TNF, IL-1 : neuroinflammation Transcriptomics and epigenomics Hippocampal RNA-seq after chronic administration of Semax or Selank often reveals a neurotrophic activation signature (BDNF, NT3, NGF, NR4A1-3) coupled with anti-inflammatory modulation (NF-B targets down)

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Authors : Enrico Gerace, Jessica Modaffari, Pierre Negri, Daniele Di Corcia, Eleonora Amante, Alberto Salomone, Marco Vincenti Source : A simple and effective procedure based on a fast methanolic extraction and a LC-HRMS detection of the growth hormone secretagogue ipamorelin in DBS was recently proposed by Gerace et al

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J Asian Pac J Cancer Prev

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Supports Muscle Growth, Repair & Recovery Increased GH promotes protein synthesis, lean muscle development, and faster recovery from exercise or injury

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