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Passive targeted delivery involves the use of carrier systems that prolong residence time and increase bioavailability, leading to higher therapeutic efficacy
The greater concern is chronic accumulation over years of continuous use, which cycling protocols address by providing regular breaks
A 2020 paper in Molecules characterised that the AEDG peptide stimulated gene expression and protein synthesis during neurogenesis, with possible epigenetic modulation through histone-modification routes (PMID 32019204)
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